�For the first clock time in the United States, more than 200 scientists from round the world will gather to explore research challenging conventional theories about immunology, inflammation and their link to acuate and continuing diseases. The Damage Associated Molecular Pattern Molecules (DAMPs) and Alarmins Symposium will be held at the Hillman Cancer Center, 5115 Centre Ave., Pittsburgh, Aug. 30 through Sept. 2.
DAMPs and alarmins ar the molecules in the body that promote healing after events such as heart attacks, strokes and car accidents. According to Michael Lotze, M.D., conductor of Strategic Partnerships for the University of Pittsburgh Cancer Institute and co-director of the symposium, they promote a sterile inflammation that comes from inner cells.
"At this dot, it is well-understood that continuous inflammation is also linked to chronic diseases such as diabetes, creaky arthritis and most cancers, particularly those occurring in adults," aforementioned Dr. Lotze. "In the past, the prevailing scientific notion was that pathogen-associated molecular patterns, or PAMPs, cause excitement by activation the immune system when pathogens such as viruses, parasites, fungi and bacteria invade the body. This type of immune response occurs in the setting of infection. At this symposium, scientists will present research linking the DAMPs inflammatory response to chronic diseases, including arthritis, corpulency, atherosclerosis and cancer."
According to Dr. Lotze, electric current theories of inflammation ar based on the notion that excitement is caused by forces outside the body, such as pathogens, while the DAMPs theory of lighting suggests that it arises internally from the body's very cells.
The symposium, which includes oral and poster presentations, brings together world-renowned researchers from across the globe, including:
-Marco Bianchi, M.D., of the H. San Raffaele Scientific Institute in Milano, Italy, a former conference director who start demonstrated the link of HMGB1 with necrosis
- Polly Matzinger, Ph.D., of the National Institute of Allergy and Infectious Diseases, proponent of the Danger Theory of Immunity world Health Organization first coined DAMPs
-Ruslan Medzhitov, M.D., of the Howard Hughes Medical Institute at Yale University, the keynote lecturer who ascertained the signal molecules knotty in responding to PAMPs
-Shigekazu Nagata, Ph.D., of the Graduate School of Medicine at Kyoto University in Kyoto, Japan, world Health Organization identified many of the signaling events important in inflammation and immunity, including interferons and the response to DNA
-Jeffrey L. Platt, M.D., of the University of Michigan in Ann Arbor, booster of the role of innate resistance in transplanting and cancer
-Jean-Marc Reichhart, Ph.D., of the Institute of Molecular and Cell Biology in Strasbourg, France, world Health Organization explores ancient responses in fruit flies to harm
-Anna Rubartelli, M.D., director of the Cell Biology Laboratory in Genova, Italy, who has discerned how biology is turned top side down when inside cellular contents come outside the cell and who, along with Drs. Lotze and Helena Harris from Sweden, co-directs the symposium
The symposium is sponsored by the University of Pittsburgh Center for Continuing Education in the Health Sciences, the Society of Innate Immunity, the Federation of Clinical Immunology Societies, the National Cancer Institute, the Office of Orphan Diseases of the National Institutes of Health, the International Society for Biologic Therapy of Cancer and the Society of Leukocyte Biology.
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